Xpa-IB

Ibuprofen + Paracetamol ·Aristopharma Ltd.·Tablet

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Packages & prices

Pack	Price	Details
Unit Price	৳ 120.00	Unit Price: ৳ 2.00 (6 x 10: ৳ 120.00)

Administration

Route of administration: This tablet should be taken in oral route with food.

The recommended dose: One 200/500 tablet or two 125/250 tablets three times daily (every 8 hours). If necessary, maximum two 200/500 tablets may be taken three times daily. Leave at least six hours between doses. Do not take more than 3000 mg paracetamol and 1200 mg ibuprofen in any 24 hour period.

Use in children and adolescents: Safety and effectiveness have not been established in children and adolescents below 18 years of age.

Effects

The most common side effects are abdominal pain and discomfort, vomiting, diarrhoea, nausea, dyspepsia, hyperhidrosis, increased serum creatinine and blood urea and abnormal liver function tests.

Indications

Xpa-IB tablet is indicated for the temporary relief of mild to moderate pain which has not been relieved by ibuprofen or paracetamol individually (such as migraine, headache, backache, menstrual pain, dental pain, rheumatic and joint pain, muscular pain, cold and flu symptoms, sore throat and fever).

Pharmacology

Paracetamol is a para-aminophenol derivative with analgesic and antipyretic properties and weak anti-inflammatory activity. It’s analgesic effect may include inhibition of central prostaglandin synthesis and modulation of inhibitory descending serotonergic pathways while its antipyretic property may be due to reduced production of prostaglandin in the hypothalamus. Ibuprofen is an NSAID which has analgesic, anti-inflammatory and antipyretic properties. It inhibits COX-1 and COX-2 enzymes, thereby also inhibiting prostaglandin synthesis.

Precautions

Caution should be taken in patient with existing or history of bronchial asthma or allergic disease, hypertension, mild to moderate CHF, mixed connective tissue disorder, SLE, non-cirrhotic alcoholic liver disease, G6PD deficiency, chronic malnutrition, anorexia, bulimia, cachexia, dehydration, hypovolemia and elderly patients. The patient should be monitored regularly for gastrointestinal bleeding. Renal function should be monitored with renal, cardiac, liver impairment, those taking diuretics and the elderly.