Sorianil

Roflumilast (Cream) ·Incepta Pharmaceuticals Ltd.·Cream

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Packages & prices

Pack	Price	Details
30 gm tube	৳	30 gm tube: ৳ 250.00

Administration

Roflumilast cream should be applied on affected areas once daily and rubbed in completely. Hands should be washed after application, unless the cream is for treatment of the hands. Roflumilast cream is for topical use only and not for ophthalmic, oral, or intravaginal use or as directed by the physician.

Use in Children and Adolescents: The safety and effectiveness of Roflumilast cream have not been established in patients aged less than 12 years.

Effects

The reported side effects (41%) are hives, swelling of your face & lips, application site pain, headache, diarrhoea, insomnia, upper respiratory tract infections and urinary tract infections

Indications

Sorianil cream is indicated for topical treatment of plaque psoriasis, including intertriginous areas, in patients 12 years of age and older.

Pharmacology

Roflumilast and its active metabolite (roflumilast N-oxide) are inhibitors of PDE4 enzyme. Roflumilast and Roflumilast N-oxide inhibition of PDE4 (a major cyclic 3', 5'-adenosine monophosphate or, cyclic AMP metabolizing enzyme) activity leads to accumulation of intracellular cyclic AMP, thus providing anti-inflammatory & immunomodulatory effects. The specific mechanism by which Roflumilast exerts its therapeutic action is not well-defined.

Precautions

Use of Sorianil with oral contraceptives containing gestodene and ethinyl estradiol should be avoided. This may increase the systemic concentration of Sorianil and increase the side effects