Somazin

Citicoline Sodium ·Popular Pharmaceuticals PLC·IM/IV Injection

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Packages & prices

Pack	Price	Details
4 ml ampoule	৳ 700.00	4 ml ampoule: ৳ 140.00 (1 x 5: ৳ 700.00)

Administration

Oral:

Immediate treatment of stroke due to a clot (ischemic stroke): 500-2000 mg of Citicoline per day, start within 24 hours of stroke.
For decline in thinking skills due to stroke: 1000-2000 mg of Citicoline per day.
Chronic cerebrovascular disease: 1000 mg daily in divided dose with or between meals for ongoing disease of the blood vessels that serve the brain.

Injection:

1 to 2 injections daily.
Adjust dosage according to the severity.
Can be administered through intramuscular (IM), or intravenous (IV) [ 3 to 5 minutes] route.

Geriatric use: No dosage adjustment is required & the usual dose can be administered.

Effects

Occasionally Somazin may exert stimulating action of the parasympathetic system as well as a fleeting & discrete hypotensive effect.

Indications

Pharmacology

Citicoline is a naturally occurring substance that is an essential intermediate in the synthesis of structural phospholipids of cell membrane. Oral dose of Citicoline is metabolized to choline & cytidine. These then enter into the systemic circulation, cross the blood-brain barrier and recombine to form Citicoline within the central nervous system. Citicoline activates the biosynthesis of structural phospholipids in the neuronal membrane, promotes rapid repair of injured cell surface & mitochondrial membrane & increases the level of various neurotransmitters like acetylcholine & dopamine. Citicoline has neuroprotective effects in situations of hypoxia & ischemia, as well as improved learning & memory performance in animal models for the aging brain. Citicoline inhibits the activation of Phospholipase A2 to prevent apoptotic & necrotic cell death.

Precautions

Somazin is known to cause increased dizziness or drowsiness. So, it is strongly recommended that patients do not operate any type of machinery throughout the course of treatment. Somazin may cause hypotension and in case necessary the hypotensive effect can be treated with corticosteroids or sympathomimetic. In case of persistent intracranial hemorrhage, the very slow administration [30 drops/minutes] is recommended; the administration of larger doses could provoke an increase of the cerebral blood flow. The patient should not consume alcohol while taking Somazin.