Prostol

Terazosin Hydrochloride ·Drug International Ltd.·Capsule

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Packages & prices

Pack	Price	Details
Unit Price	৳	Unit Price: BDT 5.00 (50's pack: BDT 250.00)

Administration

Benign Prostatic Hyperplasia-

Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded.
Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 5-10 mg administered once a day.

Hypertension-

Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded.
Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 2-10 mg administered once a day.

Effects

Postural hypotension is more commonly reported side effect. Dizziness, lack of energy, peripheral oedema; urinary frequency and priapism reported.

Acute overdose may lead to acute hypotension, cardiovascular support is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in a supine position. At the same time expansion of plasma volume and noradrenergic vasopressor may also be needed.

Indications

Terazosin Hydrochloride is indicated in-

Single therapy is used to relieve from signs and symptoms of benign prostatic hyperplasia (BPH).
For the treatment of hypertension.

Pharmacology

Terazosin is selective for alpha-1-adrenoceptors but not their individual subtypes. Inhibition of these alpha-1-adrenoceptors results in relaxation of smooth muscle in blood vessels and the prostate, lowering blood pressure and improving urinary flow. Smooth muscle cells accounts for roughly 40% of the volume of the prostate and so their relaxation reduces pressure on the urethra.

It has also been shown that catecholamines induce factors responsible for mitogenesis and alpha-1-adrenergic receptor blockers inhibit this effect. A final long term mechanism of terazosin and other alpha-1-adrenergic receptor blockers is the induction of apoptosis of prostate cells. Treatment with terazosin enhances the expression of transforming growth factor beta-1 (TGF-beta1), which upregulates p27kip1, and the caspase cascade

Precautions

First dose may cause hypotension (within 30-90 minutes). Therefore should be taken on retiring to bed.
Caution should be observed when Terazosin is administered with other antihypertensive agents, avoid the possibility of significant hypotension. When adding Terazosin to a diuretic or other antihypertensive agent, dosage reduction and retitration may be necessary.
The patients should be cautioned to avoid situation such as driving and hazardous tasks where injury could result due to syncope after initiation of Terazosin therapy.