Pronil DS

Secnidazole ·ACME Laboratories Ltd.·Tablet

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Packages & prices

Pack	Price	Details
Unit Price	৳	Unit Price: BDT 16.11 (8's pack: BDT 128.88)

Administration

Secnidazole tablet should be administered orally. The dosage schedule of is mentioned below:

Acute Intestinal Amoebiasis:

Adults: 2 gm single dose, taken preferably just before meal.
Children: 30 mg/kg single dose, taken preferably just before meal.

Asymptomatic Amoebiasis (minute& cystic form):

Adults: 2 gm once daily for only 3 days, taken preferably just before meal.
Children: 30 mg/kg once daily for only 3 days, taken preferably just before meal.

Hepatic Amoebiasis: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis.

Adults: 1.50 gm/day in a single or divided doses, just before meal, for 5 days.
Children: 30 mg/kg/day, in a single or divided dose, just before meal, for 5 days.

Giardiasis:

Adults: 2 gm single dose, taken preferably just before meal.
Children: 35-50 mg/kg single dose, taken preferably just before meal.

Trichomoniasis:

Adults: 2 gm single dose, taken preferably just before meal. The partner should also receive the same treatment concomitantly.

Effects

The clinical studies have shown that Secnidazole is characterized by very good tolerance and no serious adverse reactions have been reported to date. The following side-effects may be observed with Secnidazole as with all nitroimidazole derivatives & are rarely serious:

Most frequent side-effects: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, stomatitis.
Occasional side effects: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.
Rare side-effects: Vertigo, ataxia and motor incoordination, paresthesia, peripheral neuropathy. With Secnidazole, gastrointestinal disorders e.g. nausea, vomiting, eoigastric pain, etc., have been reported in very rare cases.

Indications

Secnidazole is indicated in-

Intestinal Amoebiasis
Hepatic Amoebiasis
Urethritis and vaginitis due to Trichomonas vaginalis
Giardiasis

Pharmacology

Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole. The plasma elimination half-life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Secnidazole gives it the longest half-life of second-generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.

Precautions

Patients should be advised not to take alcohol during treatment with Secnidazole (because of the possibility of antabuse effect). Administration of Secnidazoleshould be avoided to patients with a history of blood dyscrasia.