Peflox

Pefloxacin Mesylate Dihydrate ·Drug International Ltd.·Tablet

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Packages & prices

Pack	Price	Details
Unit Price	৳	Unit Price: BDT 11.05 (20's pack: BDT 221.00)

Administration

Adult with normal hepatic function: Pefloxcin 400 mg tablet 12 hourly (morning & evening) with meals to avoid gastrointestinal disturbances. An initial loading dose of 800 mg may be given in order to produce effective blood concentration more rapidly.

Adult with hepatic insufficiency: In patients with severe hepatic insufficiency or reduced blood supply to the liver, the daily doses should be readjusted by increasing the intervals between doses. Dosage need not to be reduced in renal insufficiency.

Duration of Treatment:

Usually 5 to 10 days.
For chronic prostatitis, cystic fibrosis & chronic Salmonella carriers: 14 days.
For endocarditis: Up to 6 months.
For chronic osteomyelitis: Up to 1 year.
For gonorrhoea: 2 tablets single dose.

Effects

Occasionally observed reactions are - Gastrointestinal disturbance: Epigastric pain, nausea, vomiting, diarrhoea, dyspepsia. Central nervous system disturbance: Headache, insomnia. Hypersensitivity reaction: Skin rash, pruritis, photosensitization. Others: Myalgia and/or arthralgia, tendonitis, rupture of achilles tendon.

Indications

Pefloxacin is indicated in adult for the treatment of single infection or mixed infections caused by two or more susceptible microorganisms. It can also be used for infections caused by organisms resistant to other antibiotics. Pefloxacin is indicated to the following manifestations:

Gastrointestinal infection: Enteric fever, acute bacterial diarrhoea & chronic Salmonella carriers.
Urinary tract infection: Cystitis, pyelonephritis, prostatitis, epididymitis, uncomplicated and complicated urethritis.
Respiratory tract infection: Pneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis, empyema.
Ear, nose and throat infection: Otitis media, otitis externa, sinusitis, tonsillitis.
Bone and joint infection: Osteomyelitis, arthritis.
Skin and soft tissue infection: Infected ulcer, wound infection, abscess, cellulitis, erysipelas and infected burn.
Pelvic infection: Salpingitis, endometritis, pelviperitonitis.
Abdominal and hepatobiliary infection: Peritonitis, intra abdominal abscess and cholingitis, cholecystitis and empyema of the gall bladder.
Also used in septicemia, bacteraemia, gonorrhoea, endocarditis, meningitis.

Pharmacology

Pefloxcin is a synthetic antibacterial agent, belongs to fluoroquinolone group. It exerts its action by inhibiting the subunit-A of DNA gyrase (Topoisomerase II). Pefloxcin is bactericidal and has a broad spectrum of activity.

Precautions

Because of the risk of photosensitivity reaction, exposure to sunlight and ultraviolet radiation should be avoided during Pefloxacin therapy. Dosage readjustment is required in severe hepatic insufficiency. Patients should be informed of the possibility of pain in the achilles tendon.