Pediphen

Diphenhydramine Hydrochloride ·Somatec Pharmaceuticals Ltd.·Syrup

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Packages & prices

Pack	Price	Details
100 ml bottle	৳	100 ml bottle: BDT 38.00

Administration

Adult-

Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night.

Children-

1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day
More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day

Effects

Side effect includes sedation, dizziness, tinnitus, fatigue, ataxia, blurred vision, diplopia, euphoria, and epigastric discomfort.

Symptoms: Impaired consciousness; psychosis, seizures, antimuscarinic symptoms (e.g. mydriasis, tachycardia, tachyarrhythmias), resp failure, rhabdomyolysis; acute delirium with visual and auditory hallucination (topical).

Management: Supportive and symptomatic treatment. Convulsions and marked CNS stimulation may be treated with IV diazepam.

Indications

Diphenhydramine is indicated for the treatment of followings:

Seasonal, perennial, vasomotor rhinitis
Urticaria, angioneurotic oedema, anaphylaxis
Pruiritic conditions
Premedication for emesis and motion sickness
Miscellaneous like meniere's disease and parkinsonism

Pharmacology

Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.

Precautions

Caution should be exercised with patients in whom drowsiness is undesirable e.g., drivers, machine operators. Concomitant consumption of alcohol or central nervous system (CNS) depressants will potentiate drowsiness.