Optimox

The dose of Moxifloxacin is 400 mg once daily. The duration of therapy depends on the type of infection as described in following:

• Acute Bacterial Sinusitis: 400 mg once daily for 10 days.
• Acute Bacterial Exacerbation of Chronic Bronchitis: 400 mg once daily for 5 days.
• Community Acquired Pneumonia: 400 mg once daily for 7-14 days.
• Uncomplicated Skin and Skin Structure Infections: 400 mg once daily for 7 days.
• Complicated Skin and Skin Structure Infections: 400 mg once daily for 7-21 days.
• Complicated Intra-Abdominal Infections: 400 mg once daily for 5-14 days.

Treatment with Moxifloxacin (oral, IV or sequential therapy) may cause some side effects. Common (>1%) side effects include headache, nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, dizziness, pyrexia and insomnia etc. Less common (0.1 to <1%) side effects include neutropenia, palpitations, tachycardia, bradycardia, vertigo, tinnitus, dry mouth, gastritis, edema, fatigue, malaise, hyperglycemia, anorexia, hyperlipidemia, hypoglycemia, dehydration, back pain and arthralgia etc.

Moxifloxacin infusion is indicated for treating following infections in adults >18 years of age caused by designated, susceptible bacteria.

• Acute Bacterial Sinusitis
• Acute Bacterial Exacerbation of Chronic Bronchitis
• Community Acquired Pneumonia
• Skin and Skin Structure Infections: Uncomplicated and Complicated
• Complicated Intra-Abdominal Infections.

Fluoroquinolones, including Moxifloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Fluoroquinolones have neuromuscular blocking activity and may exacerbate muscle weakness in persons with myasthenia gravis. Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Moxifloxacin, and may range in severity from mild diarrhea to fatal colitis.

4-Quinolone preparations