Nafinex

Naftifine Hydrochloride ·Everest Pharmaceuticals Ltd.·Cream

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Administration

For topical use only. Naftifine Cream is not for ophthalmic, oral, or intravaginal use. Apply a thin layer of Naftifine Cream once-daily to the affected areas plus a ½ inch margin of healthy surrounding skin for 2 weeks

Effects

The most common adverse reaction (≥1%) is pruritus.

Indications

Naftifine cream is an allylamine antifungal indicated for the treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum

Pharmacology

Although the exact mechanism of action against fungi is not known, naftifine appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.

Precautions

If redness or irritation develops with the use of Naftifine Cream treatment should be discontinued.

Therapeutic

Topical Antifungal preparations

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