Mastel

Mizolastine ·Advanced Chemical Industries PLC·Tablet (Modified Release)

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Packages & prices

Pack	Price	Details
Unit Price	৳	Unit Price: BDT 6.50 (30's pack: BDT 195.00)

Administration

Adult and children above 12 years: The usual recommended dose is one 10 mg tablet daily.
Children below 12 years: Not recommended.

Effects

Mizolastine is well tolerated in the recommended doses. The usual side effects are dry mouth, diarrhoea, abdominal pain, nausea, drowsiness, headache, dizziness, raised liver enzymes, hypotension, tachycardia and palpitations. Bronchospasm and aggravation of asthma were reported, but in view of the high frequency of asthma in the treated patient population, a causality relationship remains uncertain.

In cases of overdosage, general symptomatic surveillance with cardiac monitoring including QT interval and cardiac rhythm for at least 24 hours is recommended, along with standard measures to remove any unabsorbed drug. Studies in patients with renal insufficiency suggest that haemodialysis does not increase clearance of the drug.

Indications

Mizolastine is indicated for the symptomatic relief of the following conditions:

Seasonal allergic rhinoconjunctivitis (hay fever)
Perennial allergic rhinoconjunctivitis
Urticaria

Pharmacology

Mizolastine, a non-sedating antihistamine, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also has mast-cell stabilising properties.

Precautions

Patients should be warned that a small number of individuals may experience sedation. It is therefore advisable to determine individual response before driving or performing complicated task.