Bupro-D

Dextromethorphan + Bupropion ·Square Pharmaceuticals PLC·Tablet (Extended Release)

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Packages & prices

Pack	Price	Details
Unit Price	৳ 450.00	Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)

Administration

Starting dosage: One tablet once daily in the morning. After 3 days, increase to the maximum recommended dosage of one tablet twice daily, separated by at least 8 hours. Do not exceed two doses within the same day.

Use in children & adolescents: The safety and effectiveness of this tablet have not been established. Antidepressants, including bupropion, increase the risk of suicidal thoughts and behaviors in pediatric patients.

Moderate renal impairment: One tablet by mouth once daily in the morning.

Effects

Dizziness, headache, somnolence
Diarrhea, dry mouth
Sexual dysfunction
Hyperhidrosis

Indications

Bupro-D tablet is indicated in major depressive disorder (MDD) in adults.

Pharmacology

This is a combined preparation of Dextromethorphan Hydrobromide and Bupropion Hydrochloride. Dextromethorphan is an uncompetitive antagonist of the NMDA receptor (an ionotropic glutamate receptor) and a sigma-1 receptor agonist. The mechanism of Dextromethorphan in the treatment of MDD is unclear. The mechanism of action of bupropion in the treatment of MDD is unclear; however, it may be related to noradrenergic and/or dopaminergic mechanisms. Bupropion increases plasma levels of Dextromethorphan by competitively inhibiting cytochrome P450 2D6, which catalyzes a major biotransformation pathway for Dextromethorphan. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake of serotonin.

Precautions

Seizure: Risk is dose-related. Discontinue if seizure occurs.
Increased Blood Pressure and Hypertension: Bupro-D can increase blood pressure and cause hypertension. Assess blood pressure before initiating treatment and monitor periodically during treatment.
Activation of Mania or Hypomania: Screen patients for bipolar disorder.
Psychosis and Other Neuropsychiatric Reactions: Instruct patients to contact a healthcare provider if such reactions occur.