Brofex TS

Dextromethorphan Polistirex ·Square Pharmaceuticals PLC·Extend Release Suspension

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Packages & prices

Pack	Price	Details
100 ml bottle	৳	100 ml bottle: ৳ 100.00

Administration

Adults and children 12 years of age and over: 10 ml every 12 hours. Do not exceed 20 ml in 24 hours.

Children (06-12 years): 5 ml every 12 hours. Do not exceed 10 ml in 24 hours.

Children (04-06 years): 2.5 ml every 12 hours. Do not exceed 5 ml in 24 hours.

Children under 04 years of age: Not Recommended.

Effects

Adverse effects with Brofex TS are rare, but nausea and dizziness sometimes occur. The drug produces no analgesia or addiction and little or no CNS depression. Excitation, confusion and respiratory depression may occur after over dosage.

Indications

Brofex TS Extended Release Suspension is indicated in-

Chronic dry cough
Unproductive cough
Acute dry cough, which is interfering with normal function or sleep.

Pharmacology

Dextromethorphan Hydrobromide is a cough suppressant, which has a central action on the cough center in the medulla. Although structurally related to morphine, it has no analgesic properties and in general, it has little sedative activity. Addiction has not been observed after the administration of rather large doses for prolonged period. It is rapidly absorbed from the Gl tract and exerts its effects in 15-30 minutes after oral administration. Polistirex forms a matrix around the Dextromethorphan particles, which slows down the dissolution of the Dextromethorphan in the gastrointestinal tract, leading to a gradual and prolonged release of Dextromethorphan into the bloodstream. The duration of action is 12 hours with extended release suspension dosage form. Dextromethorphan Hydrobromide is extensively metabolized in the liver and excreted in the urine as unchanged Dextromethorphan and de-methylated metabolites including Dextrophan, which has some cough suppressant activity. Urinary excretion of parent and metabolites accounts for up to 50% of the ingested dose over 24 hours. About 8% of the dose is excreted unchanged in the urine over the first 6 hours.