Briva

Pack	Price	Details
Unit Price	৳ 400.00	Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)

Brivaracetam tablet or oral solution is taken in oral route. It may be taken with or without food. The recommended dose for patients 1 month of age and older is included below. In pediatric patients weighing less than 50 kg, the recommended dosing regimen is dependent upon body weight. When initiating treatment, gradual dose escalation is not required. Dose should be adjusted based on clinical response and tolerability.

Adults (16 years and older)-

• Initial dose: 50 mg twice daily (100 mg per day)
• Minimum and maximum maintenance dose: 25 mg to 100 mg twice daily (50 mg to 200 mg per day)

Pediatric patients weighing 50 kg or more-

• Initial dose: 25 mg to 50 mg twice daily (50 mg to 100 mg per day)
• Minimum and maximum maintenance dose: 25 mg to 100 mg twice daily (50 mg to 200 mg per day)

Pediatric patients weighing 20 kg to less than 50 kg-

• Initial dose: 0.5 mg/kg to 1 mg/kg twice daily (1 mg/kg to 2 mg/kg per day)
• Minimum and maximum maintenance dose: 0.5 mg/kg to 2 mg/kg twice daily (1 mg/kg to 4 mg/kg per day)

Pediatric patients weighing 11 kg to less than 20 kg-

• Initial dose: 0.5 mg/kg to 1.25 mg/kg twice daily (1 mg/kg to 2.5 mg/kg per day)
• Minimum and maximum maintenance dose: 0.5 mg/kg to 2.5 mg/kg twice daily (1 mg/kg to 5 mg/kg per day)

Pediatric patients weighing less than 11 kg-

• Initial dose: 0.75 mg/kg to 1.5 mg/kg twice daily (1.5 mg/kg to 3 mg/kg per day)
• Minimum and maximum maintenance dose: 0.75 mg/kg to 3 mg/kg twice daily (1.5 mg/kg to 6 mg/kg per day)

Geriatric use: Dose selection for an elderly patient should be judicious, usually starting at the low end of the dosing range.

Renal impairment: Dose adjustments are not required for patients with impaired renal function. Use of brivaracetam is not recommended in patients with end stage renal disease undergoing dialysis.

Use in children and adolescents: Safety and effectiveness in pediatric patients below the age of 1 month have not been established.

The most common side effects are nausea/vomiting, constipation, somnolence and sedation, dizziness, fatigue, cerebellar coordination and balance disturbances and irritability.

Briva is indicated for the treatment of partial onset seizures in patients 1 month of age and older.

This is a preparation of Brivaracetam which is an anticonvulsant. The precise mechanism by which Brivaracetam exerts its anticonvulsant activity is not known. Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain which may contribute to the anticonvulsant effect.

Antiepileptic drugs (AEDs), including Briva, increase the risk of suicidal thoughts or behavior. Patients treated with any AED should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior and/or any unusual changes in mood or behavior. Briva causes somnolence, fatigue, dizziness and disturbance in coordination. Patients should be monitored for these signs and symptoms and advised not to drive or operate machinery. Briva causes psychiatric adverse reactions which included both non-psychotic symptoms (irritability, anxiety, nervousness, aggression, belligerence, anger, agitation, restlessness, depression, depressed mood, tearfulness, apathy, mood swings, psychomotor hyperactivity, abnormal behavior and adjustment disorder) and psychotic symptoms (psychotic disorder along with hallucination, paranoia, acute psychosis and psychotic behavior). As with most antiepileptic drugs, Briva should generally be withdrawn gradually because of the risk of increased seizure frequency and status epilepticus.

Adjunct anti-epileptic drugs

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