Bexovid

Nirmatrelvir + Ritonavir ·Beximco Pharmaceuticals Ltd.·Tablet

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Packages & prices

Pack	Price	Details
6 tablet combipack	৳	6 tablet combipack: ৳ 3,200.00

Administration

Initiate this tablet treatment as soon as possible after diagnosis of COVID-19 and within 5 days of symptom onset. Administer orally with or without food.

Dosage: 300 mg Nirmatrelvir (two 150 mg tablets) with 100 mg Ritonavir (one 100 mg tablet), with all three tablets taken together twice daily for 5 days. Dose reduction for moderate renal impairment (eGFR ≥30 to <60 mL/min): 150 mg Nirmatrelvir (one 150 mg tablet) with 100 mg Ritonavir (one 100 mg tablet), with both tablets taken together twice daily for 5 days.

This tablet is not recommended in patients with severe renal impairment (eGFR <30 mL/min). This is not recommend in patients with severe hepatic impairment (Child-Pugh Class C).

Effects

Adverse events (incidence >1% and subject difference) were dysgeusia, diarrhea, hypertension, and myalgia.

Indications

Pharmacology

Nirmatrelvir is a Peptidomimetic inhibitor of the SARS-CoV-2 main protease (Mpro), also referred to as 3C-like protease (3CLpro) or nsp5 protease. Inhibition of SARS-CoV-2 Mpro renders it incapable of processing polyprotein precursors, preventing viral replication. Nirmatrelvir inhibited the activity of recombinant SARS-CoV-2 Mpro in a biochemical assay with a ki value of 3.1 nM and an IC50 value of 19.2 nM. Nirmatrelvir was found to bind directly to the SARS-CoV-2 Mpro active site by X-ray crystallography. Ritonavir is an HIV-1 protease inhibitor but is not active against SARS-CoV-2 Mpro. Ritonavir inhibits the CYP3A-mediated metabolism of Nirmatrelvir, resulting in increased plasma concentrations of Nirmatrelvir.

Precautions

The concomitant use of this tablet and certain other drugs may result in potentially significant drug interactions. Consult the full prescribing information prior to and during treatment for potential drug interactions.

Hepatotoxicity: Hepatic transaminase elevations, clinical hepatitis, and jaundice have occurred in patients receiving Ritonavir.

HIV-1 Drug Resistance: This tablet use may lead to a risk of HIV-1 developing resistance to HIV protease inhibitors in individuals with uncontrolled or undiagnosed HIV-1 infection.