Beviprex

Glycopyrronium Bromide + Formoterol Fumarate ·Square Pharmaceuticals PLC·Metered-Dose Inhaler (MDI)

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Packages & prices

Pack	Price	Details
120 metered doses	৳	120 metered doses: ৳ 450.00

Administration

Adults: Should be administered as 2 puffs twice daily, in the morning and in the evening.

Use in patients with severe renal impairment should be considered if the potential benefit of the treatment outweighs the risk.

Effects

The most common adverse reactions include cough and urinary tract infection. Possible side effects are sudden breathing problems, headache, tremor, nervousness, rash, swelling of the face, mouth and tongue, hives, increase blood pressure, chest pain, irregular heartbeat, muscle spasm, muscle weakness, eye pain or discomfort and urinary retention.

Indications

Beviprex is indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.

Pharmacology

This preparation contains two bronchodilators: Glycopyrronium is a long-acting muscarinic antagonist (LAMA) and Formoterol is a long-acting β2-adrenergic agonist (LABA) with a rapid onset of action. Glycopyrronium has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of the M3 receptor at the smooth muscle leading to bronchodilation. Formoterol causes direct relaxation of airway smooth muscle as a consequence of the increase in cyclic AMP through activation of adenylyl cyclase.

Precautions

Beviprex should not be used with an additional medicine containing a LABA because of risk of overdose.
Not indicated for the relief of acute bronchospasm
Do not initiate in acutely deteriorating COPD or to treat acute symptoms
If paradoxical bronchospasm occurs, discontinue Beviprex and institute alternative therapy
Use with caution in patients with cardiovascular disorders
Use with patients with convulsive disorders, thyrotoxicosis, diabetes mellitus and ketoacidosis.
Be alert to hypokalemia and hyperglycemia
Worsening of narrow angle glaucoma may occur. Use with caution with patients with narrow-angle glaucoma
Worsening of urinary retention may occur. Use with caution with patients with prostatic hyperplasia or bladder-neck obstruction