Beuflox

Ciprofloxacin (Ophthalmic) ·Incepta Pharmaceuticals Ltd.·Ophthalmic Solution

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Packages & prices

Pack	Price	Details
5 ml drop	৳	5 ml drop: ৳ 40.00

Administration

For Corneal Ulcers: Instill 2 drops into the affected eye every 15 minutes for the first six hours and then 2 drops into the affected eye every 30 minutes for the remainder of the first day. On the second day, instill 2 drops into the affected eye hourly. On the third through the fourteenth day, place 2 drops into the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.

Bacterial Conjunctivitis/Blepharitis: Instill 1 drop to the conjunctival sac(s) every two hours for two days and 1 drop every four hours for the next five days.

Pediatric use: Safety and effectiveness in children under 1 year of age have not been established.

Effects

The most frequently reported drug related adverse reaction was local burning or discomfort. In corneal ulcer studies with frequent administration of the drug, white crystalline precipitates were seen in approximately 17% of patients. Other reactions occurring in less than 10% of patients included lid margin crusting, crystals/scales, foreign body sensation, itching, conjunctival hyperemia and a bad taste following instillation. Additional events occurring in less than 1% of patients included corneal staining, keratopathy/keratitis, allergic reactions, lid edema, tearing, photophobia, corneal infiltrates, nausea and decreased vision.

Indications

Beuflox 0.3% ophthalmic solution is indicated for the treatment of corneal ulcers, conjunctivitis, and blepharitis, which are caused by susceptible strains of bacteria.

Pharmacology

Ciprofloxacin has in vitro activity against a wide range of Gram-negative and Gram-positive organisms. Ciprofloxacin is bactericidal and acts by inhibiting the A subunits of DNA gyrase (topoisomerase) which is essential in the reproduction of bacterial DNA.

Precautions

General: As with other anti-infective, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If super-infection occurs, discontinue use and initiate alternative therapy. Beuflox should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.