A-Tetra

Tetracycline Hydrochloride ·ACME Laboratories Ltd.·Capsule

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Packages & prices

Pack	Price	Details
Unit Price	৳ 339.00	Unit Price: ৳ 3.39 (10 x 10: ৳ 339.00)

Administration

Usual adult dosage: 250 or 500 mg every 6 hours by mouth preferably 1 hour before or 2 hours after meal. Higher doses up to 3 or 4 gm daily have occasionally been given in resistant infections.

Specific Dosage Recommendation:

Brucellosis: 500 mg 6 hourly for 3 weeks.
Chlamydial infections: 500 mg 6 hourly for at least 2 weeks.
Non-specific urethritis: 500 mg 6 hourly for 7 days.
Severe acne: 1 gm/day for 2-3 weeks followed by 1 capsule daily for 3-4 months.
Gonorrhoea: Initial oral dose of 1.5 gm followed by 500 mg 6 hourly for 4 days, the total dose should be 9 gm.
Syphilis: 500 mg 6 hourly for 15 days but therapy should be continued for 30 days if the disease has been present for longer than 1 year.
Endocervical infections: 500 mg 6 hourly for 7 days.

Children over 12 years of age: 25-50 mg/kg divided in 2 or 4 equal doses. The maximum dose should not exceed the recommended adult dose.

Children below 12 years of age: Not recommended.

Administration: Tetracycline should be taken orally, an hour before or two hours after meal and therapy should be continued for up to three days after characteristic symptoms of the infection have subsided. It should be used with caution in the treatment of elderly patients where accumulation is a possibility.

Effects

Gastrointestinal disturbances e.g. glossitis, stomatitis, vaginitis or staphylococcal enterocolitis. Photosensitivity and dermatological reactions are rare. Bulging fontanelles in infants and benign intracranial hypertension in adults has been reported. Treatment should be ceased if intracranial pressure raises. Hypersensitivity reactions include purpura, pericarditis, angioneurotic oedema, anaphylaxis, anaphylactoid purpura, and exacerbation of systemic lupus erythematosus may occur. Haemolytic anaemia, thrombocytopenia, neutropenia end eosinophilia have been reported.

Indications

Pharmacology

Tetracycline is a broad-spectrum antibiotic which is bacteriostatic for manybacteria, rickettsiae, chlamydia, mycoplasma and brucella. It exerts its antimicrobial effect by inhibiting protein synthesis. After a single oral dose of Tetracycline peak plasma concentration is attained in 2 to 4 hours. The drug's half-life is in the range of 6 to 9 hours. Because of its enterohepatic circulation, Tetracycline may be present in the blood for a long time after cessation of therapy.

Precautions

Absorption of tetracycline is impaired by the concomitant administration of milk and by calcium, magnesium, iron and particularly aluminium salts commonly used as antacids. A-Tetra depresses plasma prothrombin activity. Therefore, reduced dosage of concurrent anticoagulants may be required. Lower doses are indicated in cases of renal impairment to avoid excessive systemic accumulation and if therapy is prolonged, serum level determinations are advisable. The concomitant use of oral tetracycline may reduce the efficacy of oral contraceptives and penicillins; an increased incidence of breakthrough bleeding may also be experienced. It should only be used with great caution in conjunction with other potentially hepatotoxic drugs.